Congenital Hypofibrinogenemia: A Newborn Infant with Cord Bleeding.
نویسندگان
چکیده
The genetic disorders causing decreased fibrinogen synthesis may be caused by heterozygous (hypofibrinogenemia) or homozygous (afibrinogenemia) deficiency. The consequences of the disorders are gastrointestinal bleeding, cord bleeding, eccymoses, subcutaneous hematomas and hemarthroses especially due to traumatic delivery in the neonatal period. Laboratory evaluation of the patient with hypofibrinogenemia reveals prolongation of thrombin time, partial thromboplastin time, prothrombin time and decreased fibrinogen level. We report a 21 days old, congenital hypofibrinogenemia case with cord bleeding.
منابع مشابه
Congenital hypofibrinogenemia in pregnancy: a report of 11 cases
: To investigate the obstetrical outcomes and plasma concentrations of fibrinogen (FIB) in patients with congenital hypofibrinogenemia in pregnancy, 11 cases with hypofibrinogenemia in pregnancy were analyzed retrospectively. The demographic database, bleeding tendency, plasma levels of FIB throughout pregnancy, peripartum management, as well as, maternal and neonatal outcomes were assessed. FI...
متن کاملCongenital hypofibrinogenemia.
Congenital afibrinogenemia/hypofibrinogenemia is an extremely rare coagulation disorder. We describe a case of congenital hypofibrinogenemia in a 6-year female child, who presented with recurrent ecchymotic spots with no frank bleeding.
متن کاملCongenital afibrinogenaemia and successful pregnancy outcome. Case report.
The successful outcome of pregnancy in a 25year-old woman with congenital afibrinogenaemia is discussed. She had been found to have afibrinogenaemia soon after birth, following investigation for severe bleeding from her cord stump. She frequently suffered with severe bruising, heavy menstruation and excessive blceding after dental treatment. She had had an avcrage of two to three fibrinogen tra...
متن کاملCongenital Hypofibrinogenemia Detected during Preoperative Workup for Major Cardiac Surgery
Afibrinogenemia or hypofibrinogenemia is a quantitative defect in fibrinogen. It is a rare disease with estimated frequency of 1 in 1,000,000 population. Routine preoperative screening tests of coagulation disorders are insufficient to detect subtle disorders of fibrinogen. Herein, we report a child who was supposed to undergo open cardiac surgery for a large atrial septal defect. Preoperative ...
متن کاملCongenital afibrogenaemia in a Kenyan child: case report.
Congenital afibrinogenaemia (CA), is a rare inherited bleeding disorder characterised by complete deficiency of fibrinogen in the plasma. Blood clotting tests are indefinitely prolonged in patients. The mode of inheritance is autosomal recessive. Typically patients present with excessive cord bleeding after birth with intracerebral haemorrhages reported in childhood. Other manifestations includ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Turkish journal of haematology : official journal of Turkish Society of Haematology
دوره 17 4 شماره
صفحات -
تاریخ انتشار 2000